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It is noteworthy that adipocytes release factors that promote sodium retention and volume expansion, including leptin and aldosterone, and the reduction in adipocyte mass with tirzepatide may reduce these influences 23

Animal studies showed that DSIP pretreatment could protect against stress-induced ulcers, reduce stress-induced behavioral deficits, normalize stress hormone responses, and improve performance under stressful conditions

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Each cycle worsens body composition and metabolic function

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