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Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: results from the prospective TEDDY study

Key priorities include replication in additional preclinical systems (including patient-derived oligodendrocytes), identification of molecules with reliable CNS penetration, and incorporation of biomarkers sensitive to synuclein burden and glial dysfunction

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Cao M, Liu W-W, Maxwell S et al (2023) IgG1-3 MuSK antibodies inhibit AChR cluster formation, restored by SHP2 inhibitor, despite normal MuSK, DOK7, or AChR subunit phosphorylation

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However, its primary use in IBS would be symptom management, with weight loss as a potential secondary benefit