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11,12 Platelets along with growth factors which are platelet-derived growth factors (PDGFs), transforming growth factor b1 (TGF- 1), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), insulin-like growth factor 1(IGF-1), or fibroblast growth factor (FGF) play a critical role in cell proliferation, chemotaxis, cell differentiation, and angiogenesis