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A clinical trial from the UK measured cognitive or other neurological functions in response to B12 supplements in 191 asymptomatic, non-anemic older people with low B12 levels and considered moderately deficient

A 2017 paper by Pickart and colleagues published in Brain Sciences (DOI: 10.3390/brainsci7020020) extended the gene expression analysis to nervous system function genes, relevant to the dense innervation of hair follicles and neural signaling in follicular cycling

This age-related decline has been a central focus of research interest

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The subjects used in this study were obese females and males between the ages of 18 and 65

HDAC, histone deacetylases