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doi: 10.1016/j.jbspin.2018.02.008

Moorjani investigated the histologic changes after direct application of a cryoprobe to intercostal nerves for 60 seconds [19]

References "Assessment of the Efficacy of Cryolipolysis on Abdominal Fat Deposits: A Prospective Study," Aesthetic Plastic Surgery , May 3, 2023

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Furthermore, the increment of ROS content along with the oxidative stress markers increase are suggestive of a putative activation of the p38, ERK MAPK signaling pathway (Torres, 2003)