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Mechanisms of 4-hydroxy-2-nonenal induced pro- and anti-apoptotic signaling

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Rats treated with GLXB exhibited a significant reduction in myocardial infarct size, as well as improved cardiac function and myocardial structure following myocardial I/R injury, which was likely achieved through the modulation of energy metabolism via the inhibition of the RhoA/ROCK signaling pathway (Yan et al., 2018)

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doi: 10.1016/j.jand.2015.12.006, 79