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These modifications include an Ala8Aib amino acid substitution and attachment of a C18 fatty diacid side chain at Lys26 via a linker that promotes albumin binding, significantly prolonging circulation time compared to native GLP-1

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Weight loss usually develops gradually as dosing increases and the body adjusts

Local injection site reactions, such as redness, itching, or mild swelling at the site where the needle entered the skin, are relatively common and usually resolve within a few days