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Here is what last weeks manifesto argued, and what this report now takes further: GLP-1 drugs may suppress appetite, but they do not remove the refined sugar, ultra-processed foods, fragrance chemicals, sleep debt, chronic cortisol, and spiritual confusion that filled the bucket in the first place

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Therefore, we hypothesize that deregulated homocysteine metabolism in homocystinuria with severe hyperhomocysteinemia will lead to the cyclization of homocysteine into homocysteine thiolactone, which may render LDL less susceptible to oxidation