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Another interesting aspect that should be further investigated is the fact that in most studies on synaptic plasticity, changes in neurexins are always accompanied by changes in postsynaptic adhesion molecules

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Stimulation of IR upregulates both mitogen-activated protein (MAP)/extracellular signal-regulated kinase and phosphoinositide 3-kinases/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathways and subsequently leading to inhibiting of apoptosis and promoting cell migration and proliferation [33]

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