The most immediate effect is a loss of potency
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To put that in perspective, you'd need massive amounts of oral supplements to come close to these therapeutic doses - and most wouldn't make it to your cells intact
(3) Clinical Gaps : While preclinical data (e.g., berberines 500 mg/kg dose in rats) are promising, human trials are sparse, with only cinnamon, coffee, and wheat fiber tested in modest cohorts
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appetite regulation is biology, and the biology reasserts itself when the medication leaves