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The STEP trial program demonstrated approximately 1517% weight loss over 68 weeks (Wilding et al., 2021)

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H 2 O 2 directly oxidizes the Cys81 of Atg4 (Scherz-Shouval et al., 2007), thus leading to the inactivation of Atg4 and promoting the lipidation of light chain 3 (LC3, also the mammalian homolog of Atg8), thereby supporting the formation of autophagosomes (Prez-Prez et al., 2021)