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The compound was first isolated from human plasma in the 1970s, and researchers noticed something unusual early on: plasma levels of this peptide decline with age, dropping from roughly 200 nanograms per milliliter around age 20 to about 80 nanograms per milliliter by age 60

Canagliflozin for primary and secondary prevention of cardiovascular events: results from the CANVAS program (canagliflozin cardiovascular assessment study)

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Diabetes Care 2020;43:2066-73

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Its importance in the body cant be over-estimated - low levels have been associated with several different illnesses and conditions, such as cardiovascular disease (where the health of blood vessels is crucial and glutathione may help protect them), cancer, arthritis, and more