DaiMDaiSGuLXiangZXuALuSet alEfficacy of glucagon-like peptide-1 receptor agonists in overweight/obese and/or T2DM adolescents: a meta-analysis based on randomized controlled trials
As of this writing (July 2024), we are not aware of robust head-to-head RCTs comparing GLP-1 medications outcomes to outcomes with other forms of weight loss intervention on validly-measured SMM, strength, or function
In the Random Forest analysis, Moheibacter ranked first, highlighting its primary role in regulating intramuscular fat deposition, while L-carnitine ranked second, emphasizing the crucial role of mitochondrial fatty acid oxidation in modulating intramuscular fat formation
For others, the peace of mind that comes with FDA oversight is worth the premium
There is not yet enough comparative human data to answer this definitively
doi: 10.1038/oby.2008.315 256