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doi: 10.1016/j.psj.2020.11.057 12

REDEFINE 2 (combination, with type 2 diabetes) In adults with type 2 diabetes, the combination achieved 13.7% weight reduction versus 3.4% for placebo

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The biological evidence is robust at the cellular level, and clinical results are promising but limited by small study sizes, industry sponsorship, and absence of independent replication