Male SD rats were administered a single IM injection of blank solvent (excipient), and biological samples, including whole blood, plasma, urine, feces, and tissues, were collected for background control
Transfection of Cyp2E1 [145] or induction of Cyp2E1 by dimethyl sulfoxide (DMSO) [139], can restore at least in part the metabolic capacity of HepG2 cells but the overall gene expression profile of HepG2 cells shows low similarity to primary human hepatocytes [146, 147]
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Whereas, the C-terminus undergoes amidation (conversion of the carboxyl group (-COOH) to an amide group (-NH2)
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