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Testing of metabolic competence of cells and S9-fractions PRH and PHH, HepG2 cells, and the rat and hamster S9-fractions were tested for their metabolic competence to ensure metabolic activation of the tested NAs into reactive metabolites by CYPs

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Hydrogen peroxide activates IkappaB kinases through phosphorylation of serine residues in the activation loops

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Different agonists tip this balance differently, favoring G protein signaling or arrestin recruitment to varying degrees, a phenomenon called biased agonism