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The in vivo study showed a significant reduction in TMAO levels in C57BL/6(FMO3 +/+ ) strain WT mouse models and in TMA levels in C57BL/6 -Fmo3em1Smoc (KO) mouse models

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But clinical practice has quickly shown that a meaningful subset of patients does not fit neatly into the standard protocol, and prescribers often have clinical reasons to go beyond what any commercial format can offer: Patients highly sensitive to GI side effects such as nausea who need a slower, more precise titration than any fixed-dose schedule allows

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10.1016/j.bbrc.2017.09.108 96 SuthaharN.MeijersW