Meanwhile, people with PCOS tend to have elevated levels of testosterone, which can affect the egg follicles in your ovaries, increase insulin resistance, and encourage fat storageall of which can throw off your ovulation
FXR agonists, such as OCA, inhibit BA synthesis and stellate cell activation via the FXR-SHP pathway (144), while TGR5 agonists exert anti-fibrotic effects via immunomodulation (145)
Some people may experience digestive upset, headaches, or changes in their menstrual cycle
Its particularly during periods of rapid growth like pregnancy
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However, some severe side effects require immediate medical assistance
