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These gastrointestinal side effects typically peak during weeks 6-8 and resolve significantly by week 12

doi: 10.1016/j.burns.2004.10.013

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Some animal studies have reported re-pigmentation in gray hair follicles following exposure to this compound, mediated through effects on melanocyte activity in the follicle

However, during high-fat diet (HFD) feeding, obesity and insulin resistance, the accumulation of medium-chain and long-chain acylcarnitines due to incomplete -oxidation may negatively regulate the expression of nuclear-encoded mitochondrial genes, further reducing mitochondrial number and function and creating a vicious metabolic cycle [33]