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To construct accurate data-driven estimation models, it is essential that the underlying experimental calibration data used by these models is of high fidelity and quality

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Another bile salts chemosensor is the nuclear farnesoid X receptor (FXR) (347) which activation, contrarily to TGR5, blocks the release of GLP-1 in the colonic L-cells (348), while in the liver induces glycogenesis helping to improve glucose homeostasis

Targeted delivery appears to be a challenging but achievable task with the use of novel drug delivery systems such as nanoparticles 22,23