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10.1038/s41593-021-00837-1 179

These medications may influence weight management by: Reducing appetite signals in the brain Slowing gastric emptying, which may increase feelings of fullness Supporting blood sugar regulation Helping reduce cravings in some individuals However, medication alone is rarely the full solution

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Theoharides TC, et al

The typical pattern is to taper retatrutide down, keep cagrilintide at maintenance (1.7-2.4 mg/week), then resume retatrutide after a 4-8 week washout