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Simultaneously, it downregulates genes associated with inflammation (IL-6, TNF-alpha), oxidative damage, fibrosis (TGF-beta in some contexts), and tissue destruction (certain metalloproteinases)

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Of these studies, four articles described treatment in cohorts, which had a peripheral polyneuropathy of any cause, seven studied treatment in diabetic neuropathy, two in chemotherapy induced peripheral neuropathy, and two in alcohol-related neuropathy