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Nat Rev Neurol 14(3):133150 Barisano G, Montagne A, Kisler K, Schneider JA, Wardlaw JM, Zlokovic BV (2022) Bloodbrain barrier link to human cognitive impairment and Alzheimers disease

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Indeed, it may be possible that GSHee modulates opioid receptor signaling processes that result in fentanyl becoming a biased ligand so that the opioid receptor signaling pathways now favor analgesia rather than respiratory depression 119,120

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At the same time it serves conversely as a signaling molecule to activate a rescue/defense system for restoring the redox homeostasis in plant cells