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Treatment with a histone deacetylase inhibitor, valproic acid, is associated with increased platelet activation in a large animal model of traumatic brain injury and hemorrhagic shock

Autonomic neuropathy Another neuropathic complication of diabetes mellitus is cardiac autonomic neuropathy (CAN), which occurs in as many as 25% of diabetic patients (55)

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Everything discussed below reflects findings from preclinical and in vitro studies, not clinical guidance

This review also seeks to identify gaps in knowledge and highlight potential directions for future research into redox-targeted treatments for FM