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Acknowledgments We acknowledge the traditional custodians of the lands this project was conducted on, the Wurundjeri people of the Kulin nation, Professor Freya Fowkes (Burnet Institute) for assisting with statistical analysis, Dr Philippe Boeuf (Burnet Institute) and Professor Christian Doerig (RMIT) for helpful discussions and feedback on the manuscript, Professor Patrick Humbert (La Trobe University) for providing access to flow cytometry equipment, and The Australian Red Cross Blood Bank for the supply of human erythrocytes

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Treatment with l-carnitine can upgrade the inflammatory microenvironment of KOA synovitis in vivo and inhibit the production and release of inflammatory cytokines in vitro

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