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Studies suggest that people who lose weight quickly, particularly with the aid of medications like GLP-1 receptor agonists, may have a higher likelihood of developing gallstones, which can cause severe abdominal pain and may require surgical intervention

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415 Identification of phenotypes and endotypes Arterial stiffness is a clinical syndrome caused and amplified by several modifying and/or modulating factors (e.g., obesity, CKD, diabetes, and smoking)

Oral Contraceptives and Hormone Therapies The gastric-emptying delay caused by GLP-1 medications can reduce the effectiveness of oral contraceptives, particularly with tirzepatide (Mounjaro/Zepbound)

Some describe it as a small pinch, or say they barely feel it

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