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Clinical indications include deficiency due to inadequate diet or malabsorption, drug-induced deficiency (for example, from long-term isoniazid or oral contraceptives), and certain inborn errors of metabolism (such as pyridoxine-dependent seizures or sideroblastic anemia)

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Absorbed vitamin B12 is transported via specific B12 binding proteins, transcobalamin I and II to the various tissues

Although SBOs are rare, they can happen, so you should stop all medication immediately and get medical help if needed, as they can be life-threatening

Budimirovic, D

doi: 10.3390/ht7040029 83 WagnerN.BosshartA.FailmezgerJ.BechtoldM.PankeS