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In Barretts, tissue is the issue

To meet the diagnostic criteria for mEDS, a person must meet: Major criterion 1 AND at least one other major criterion OR Major criterion 1 AND at least three minor criteria Major Criteria Congenital muscle hypotonia and/or muscle atrophy that improves with age Proximal joint contractures (knee, hip, and elbow) Hypermobility of distal joints Minor Criteria Soft, doughy skin Atrophic scarring Motor developmental delay Myopathy on muscle biopsy Periodontal EDS (pEDS) If a person meets the diagnostic criteria for pEDS, genetic testing should be done to confirm the diagnosis

The combination of speech therapy with early intensive behavioural intervention (such as ABA) produces particularly strong outcomes for young children

Glutathione functions primarily as an antioxidant, protecting cells from oxidative damage

2023 Dec;28(1):2152607

This effect was evidenced by alterations in total and ferrous iron levels in the hippocampus and an increase in the expression of PEBP1, ERK1/2, and key ferroptosis-related proteins, including GPX4, FTH1, ACSL4, and COX2 (Jiao et al., 2021)