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Increased TCDCA leads to insulin resistance that is due to impaired insulin action in the dorsal vagal complex of the hindbrain from increased local TCDCAFXR signaling 272

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DeFronzos research team is currently working on a formulation that may allow pioglitazone to work without activating peroxisome proliferator-activated receptor gamma in the brain, thus avoiding a trigger for the hunger signal

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