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Hernandez, L.A

Guanfacine, a central alpha-2 agonist, reduces sympathetic outflow from the brain

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However, improving the therapeutic window of natural hepatoprotective agents, developing drug carriers with excellent properties, and reducing their toxicity remain current and future problems to be overcome

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However, common adverse effects include nausea, vomiting, diarrhea, and constipation, which typically diminish over time with dose titration