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But the peak severity and the dropout rate suggest that the triple receptor activation, while more effective for weight loss, comes at a real cost in terms of tolerability

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In fact, since the cells of the gut will see the highest doses of metformin they will experience the greatest level of inhibited complex I which may explain the gastrointestinal side effects (nausea, diarrhea, anorexia) of the drug that limit its utility in many patients

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B12 promotes cellular detoxification and supports the degradation of fatty acids