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Machine-learning-guided directed evolution for protein engineering

Very interesting paper providing cardiologists point of view on the comparison of semaglutude and tirzepatide They conclude that semaglutide currently remains the most established option for reducing cardiovascular risk in patients with T2DM and obesity with atherosclerotic disease Tirzepatide is particularly well suited when maximal weight reduction represents the primary clinical objective

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Quickstart Highlights 5-Amino-1MQ dosage protocols center on this selective, cell-permeable NNMT (Nicotinamide N-methyltransferase) inhibitor studied for its potential to support fat metabolism, preserve lean muscle mass, and elevate intracellular NAD+ levels