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It works especially well when combined with GLP-1 agonists like semaglutide, delivering greater results than either alone

171 Aerobic and resistance training exercises also improve insulin sensitivity, vascular function, and oxidative stress, critical for long-term cardiometabolic health

So it sounds like going back to that example you said where maybe didnt work was the degenerative arthritis

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You may also benefit from continuing any IBS-specific treatments (antispasmodics, low-FODMAP diet) alongside your retatrutide protocol