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To assess the ability of GSH and GSS to discriminate between amyloid PET-positive and -negative individuals, receiver operating characteristic (ROC) curve analysis was performed using models based on biomarker concentrations alone, and in combination with age, sex, and APOE 4 carrier status

preliminary results from many of these phase 3 trials have been negative

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For example, NMR-titration experiments of non-glutathionylated poplar GrxC4 or ScGrx8 with GSH required high glutathione concentrations to detect chemical shifts 47,48 (and titrations of active site serine mutants with GSSG cannot discriminate between both glutathionyl moieties)

Curious what a realistic timeline looks like

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