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While internalization of LDL by the LDLR in hepatocytes downregulates cholesterol synthesis to maintain cholesterol homeostasis, internalization of oxLDL by scavenger receptors fails to trigger this inhibition (298,299,300)

SrHA: strontium substitution in hydroxyapatite

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Simultaneously, they significantly influence immune cell function, thereby creating an immunosuppressive environment that further enhances drug resistance ( Furthermore, immune cells in the tumor microenvironment can potentially influence drug metabolism and elimination by releasing specific cytokines and chemical substances, thereby exacerbating drug resistance mechanisms ( Cancer stem cells (CSCs) are a population of tumor cells with self-renewal and differentiation potential

Based on the results of existing studies, ALCAR effectively increases the tolerance threshold of thermal and mechanical stimuli, reduces latency, and reduces apoptosis