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Antioxidant effects of methionine, -lipoic acid, N-acetylcysteine and homocysteine on lead-induced oxidative stress to erythrocytes in rats
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Phospholipid peroxy radicals are relatively unstable and can react with Fe 2+ , resulting in a chain expansion of phospholipid peroxidation, thus triggering ferroptosis signals ( 3.4 Transcription factors and ferroptosis P53 and Nrf2, as widely reported transcription factors, participate in the metabolism of iron and reactive oxygen species by regulating SLC7A11, arachidonate 12-lipoxygenase (ALOX12) gene, NOQ1, HO-1, heme type I fluorosynthase and the frontotemporal hairline (FTHL) gene (40)
Liang R, Ghaffari S (2014) Stem cells, redox signaling, and stem cell aging