2024;7(5) doi: 10.1001/jamanetworkopen.2024.13172
Diagnostic testing Although the DNA sequence of imprinted maternally and paternally inherited alleles is the same, multiple epigenetic factors (such as DNA methylation) ultimately will determine if the allele is expressed or repressed
An early GLP-1 drug, Exendin-4, was found to reduce conditioned place preference and dopamine release in the nucleus accumbens in response to nicotine, cocaine, and amphetamine (a brain region that is understood to play a crucial role in the bodys reward system) as well as to reduce cocaine self-administration and seeking behavior in rats
What is actually being compared
Frontiers in surgery, 12, 1506780
Regul Pept (2010) 159(13):616.10.1016/j.regpep.2009.06.010 25 KimJYLeeSKJoKJSongDYLimDMParkKYet alExendin-4 increases bone mineral density in type 2 diabetic OLETF rats potentially through the down-regulation of SOST/sclerostin in osteocytes