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The Verdict: Highly variable depending on the extract

Zhang T, Qi Y, Liao M, Xu M, Bower KA, Frank JA, Shen HM, Luo J, Shi X, Chen G (2012) Autophagy is a cell self-protective mechanism against arsenic-induced cell transformation

Case reports describe serious systemic toxicity and rhabdomyolysis at mega-doses (around 6 mg) [4]

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These findings advocate for the hypothesis that calcium homeostasis in the brain, particularly under hypoxic conditions, is modulated by lactylation modifications, which in turn, have a substantial impact on the pathological mechanisms of CIRI

Shao et al., 2022