The research team used preclinical mouse models with diet-induced obesity to compare the effects of retatrutide, semaglutide, calorie restriction, and a vehicle control on cancer progression looking specifically at pancreatic ductal adenocarcinoma and lung adenocarcinoma endpoints
Semaglutide is administered via injection, making it a convenient option for those with busy schedules
And every kilogram of muscle lost reduces resting metabolic rate by ~13 kcal/day, making long-term weight maintenance much harder
Contrast this with oral semaglutide, which has fewer long-term studies overall
Dont panic, dont double-dose and get guidance if youre uncertain
Canadian 24-hour movement guidelines for adults aged 18-64 years and adults aged 65 years or older: an integration of physical activity, sedentary behaviour, and sleep