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When this happens, you might experience: Burning sensation in your chest (heartburn) Sour or bitter taste in your mouth Feeling of food coming back up Discomfort in your upper abdomen Bloating or feeling overly full after small meals Burping or belching The good news is that these symptoms are usually manageable with the right strategies, and they often improve as your body adjusts to the medication

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Solution: reduce PT-141 dose to 0.5 mg and administer it in the evening after a light meal, then add 10 mg oral domperidone (a peripheral dopamine antagonist) 30 minutes before injection to blunt the nausea reflex without crossing the blood-brain barrier