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More recently, studies have begun looking at it as a treatment for bladder issues, problems with jaw joints, and trouble smelling after a bout of COVID-19

Higher cumulative weekly exposure may intensify these effects beyond the tolerability data from once-weekly clinical trials

According to current therapeutic guidelines, the recommended pharmacological regimen for HFpEF should include SGLT2i (empagliflozin), mineralocorticoid receptor antagonists (spironolactone), angiotensin receptor-neprilysin inhibitors (sacubitril/valsartan), and angiotensin II receptor blockers (candesartan) [25]

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