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However, HIF-1 alone is insufficient to achieve the complete program of adaptive changes required for cell survival under hypoxic stress, while the unfolded protein response (UPR) responding to endoplasmic reticulum stress plays an essential supplementary role in promoting cell survival

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Journal of Autoimmunity, 153, 103414

Toward a more complete model

states as well as Canada, Australia, New Zealand, England, France, Turkey, Taiwan and Argentina

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