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In conditions of nutrient depletion, ULK1 is activated, which leads to phosphorylation of the components of the Class III PI3K vacuolar protein sorting 34 (VPS34) protein complex, resulting in the formation of autophagosome and promoting the autophagy flux [255]

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doi: 10.1111/1750-3841.15598 491 YangRShanSZhangCShiJLiHLiZ

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This effect is mediated through the same GHS-R1a receptor but in hypothalamic neurons rather than pituitary somatotrophs