Participants in the semaglutide group achieved a weight loss of at least 5%, 10%, or 15%, and improvements in secondary endpoints, such as waist circumference, blood pressure, and lipid levels, compared to the placebo group
These are legitimate concerns
Broader clinical effects influence prescribing decisions, as some analyses report a 25% reduction in cardiovascular risk among people using semaglutide, which informs benefit-risk assessments beyond weight alone
This cyclical pattern is expected and reflects the medication establishing a new equilibrium at a higher effective concentration
Im on 60 mg of duloxetine, and while I kept waiting for that breakthrough moment everyone talks about, it never came
A recent study compared semaglutide and tirzepatide for weight loss and found that tirzepatide resulted in 2.4% more weight loss at 3 months, 4.3% more at 6 months, and 6.9% more at 12 months