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Cell Metab 25 , 838855 e815, (2017)

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They were originally discovered in bone marrow but were later found in many other adult tissues, such as adipose tissue and placenta

The blend sits at the front edge of metabolic research, which is exactly why the marketing runs ahead of the evidence

1,15 Hyperglycemia-induced metabolic pathways Polyol pathway activation In a hyperglycemic state, excess glucose is shunted into the polyol pathway, where aldose reductase catalyzes its reduction to sorbitol, which in turn is oxidized to fructose by sorbitol dehydrogenase