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After first puncture, the 28-day multi-dose window starts, and refrigeration at 2-8C is consistently cited as the documented best practice in community and pharmaceutical references

Poor prognostic indicators at 24 to 48 hours post ingestion include all of the following: pH 2.6 Hepatic encephalopathy grade III (confusion and somnolence) or grade IV (stupor and coma) Hypoglycemia Thrombocytopenia Acute acetaminophen toxicity does not predispose patients to cirrhosis