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Novel approaches such as organoids, vascularized tumor-on-chip models, and genetically engineered mouse models with inducible vascular and oncogenic mutations may better replicate the interplay between tumor biology and cardiovascular stress

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However, a small sample found that Lira did not significantly change levels of the hepatic fat oxidation marker -hydroxybutyrate, although it reduced liver fat [68]

Weekly dosing maintains stable tissue levels of methyl donors and lipotropic compounds needed for consistent hepatic fat mobilisation less frequent dosing (biweekly or monthly) disrupts the methylation cycle and reduces efficacy significantly