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Their indications have since expanded to include obesity and metabolic syndrome X, fundamentally changing the medical paradigm

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doi: 10.1210/jcem.76.4.8473405 [DOI] [PubMed] [Google Scholar] 73.Weber MM

An important theme in interpreting vitamin B 12 deficiency is the remethylation block hypothesis: Vitamin B 12 deficiency results in hyperhomocysteinemia because Hcy remethylation is blocked (Selhub et al., However, a further examination of this hypothesis, for example using the topology of the metabolic network in Figure 1, shows there might be difficulties with this interpretation

Stress has also been associated with various other autoimmune conditions, including GD (32)

Longitudinal exposure of human T lymphocytes to weak oxidative stress suppresses transmembrane and nuclear signal transduction