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In the WAG/Rij epilepsy rat model, a genetic model of absence epilepsy, epileptogenesis, and mild-depression comorbidity, the acetylated levels of H3 and H4 histones were increased significantly and the decreased expressions of HDAC1 and HDAC3 were observed following NaB treatment [132]

In the one by one matched group, the interaction was significant in the ANOVA (F(1,63)=5.56, P =0.021) and the analysis of covariance (F(1,62)=5.43, P =0.023)

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