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Thomas I, Dickens AM, Posti JP, Czeiter E, Duberg D, Sinioja T, et al

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Diabetes 68 , 11091120 (2019)

Cardiovascular and Metabolic Benefits Although not yet conclusively proven, early data suggest that Tirzepatide may: Improve blood pressure and lipid profiles Reduce markers of inflammation and insulin resistance Potentially lower cardiovascular risk, though large outcome trials like SURPASS-CVOT are underway to confirm this Such benefits are particularly relevant, as cardiovascular disease is the leading cause of death among people with type 2 diabetes

You may notice the solvent being pulled from the syringe into the vial

Reduced folate/ThDP exchanger SLC19A1, demonstrating decreased transcript levels 1 month after the bypass, shares the cluster (3 g) with mitochondrial ThDP transporter SLC25A19, ThTPase and BCKDHA (Figure 5A)